2,3-difluoro-N-methoxy-N-methylbenzamide → (2,3-Difluorophenyl)(4-methoxyphenyl)methanone

HRID 1294863Notes

Reaction equation

HRID 1294863 reaction equation
[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[CH:19][CH:18]=1>>[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=1)=[O:5]

Participants

3

Reactant 2

HCID 626611902,3-difluoro-N-methoxy-N-methylbenzamideHCID 178491912HCID 178491912, compound

Product 1

HCID 62650974(2,3-Difluorophenyl)(4-methoxyphenyl)methanone

Procedure

Prepared according to Method A step B from 2,3-difluoro-N-methoxy-N-methylbenzamide (3.0 g, 15 mmol) and 4-methoxyphenylmagnesium bromide (35 mL, 0.5 M in THF) to give 1.44 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6670d87a97704d5faff159be8a326f6a
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

Loading…