HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-fluoro-N-methoxy-N,3-dimethylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Methanamine, N-methoxy-, hydrochloride (1:1) | HCID 81138 | — |
| Reactant | 2-Fluoro-3-methylbenzoic acid | HCID 2737379 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 2-fluoro-N-methoxy-N,3-dimethylbenzamide | HCID 80718058 | 74.9% |
Reaction Steps
Prepared according to Method A step A from 2-fluoro-3-methylbenzoic acid (5.0 g, 32.5 mmol), N,O-dimethylhydroxylamine hydrochloride (8.4 g, 87 mmol), oxalyl chloride (2.83 mL, 32.5 mmol) and 8 mL of pyridine to give the title compound (4.8 g) as an oil. Used as is in the next prep
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241791B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-61841e28ca6945818215ea0732a2e383 |
| Source note | uspto-grants-2007_07 |