2-fluoro-N-methoxy-N,3-dimethylbenzamide → (2-Fluoro-3-methylphenyl)(4-methoxyphenyl)methanone

HRID 1294865Notes

Reaction equation

HRID 1294865 reaction equation
[F:1][C:2]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[CH:19][CH:18]=1>>[F:1][C:2]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=1)=[O:5]

Participants

3

Reactant 2

HCID 807180582-fluoro-N-methoxy-N,3-dimethylbenzamideHCID 178491912HCID 178491912, compound

Product 1

HCID 67021114(2-Fluoro-3-methylphenyl)(4-methoxyphenyl)methanone

Procedure

Prepared according to Method A step 2-fluoro-N-methoxy-N,3-dimethylbenzamide (4.8 g, 24 mmol) and 4-methoxyphenylmagnesium bromide (50 mL, 0.5 M in THF) to give 3.7 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-077b9e2e761f401b9b31c9669b5a0f4e
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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