2,3-difluoro-N-methoxy-N-methylbenzamide → HCID 68884896, compound

HRID 1294867Notes

Reaction equation

HRID 1294867 reaction equation
[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20]([Mg]Br)=[C:19]([CH3:25])[CH:18]=1>>[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][C:19]=1[CH3:25])=[O:5]

Participants

3

Reactant 2

HCID 626611902,3-difluoro-N-methoxy-N-methylbenzamideHCID 178491917HCID 178491917, compound

Product 1

HCID 68884896HCID 68884896, compound

Procedure

Prepared according to Method A step B from 2,3-difluoro-N-methoxy-N-methyl-benzamide (3.77 g, 18.7 mmol) and 4-methoxy-2-methyl-phenylmagnesium bromide (49 mL, 0.5 M in THF) to give 1.45 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e104e33c282b4f04ab0907bd5ac6b9a0
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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