2-fluoro-N-methoxy-N,3-dimethylbenzamide → (2,4-Dimethoxyphenyl)(2-fluoro-3-methylphenyl)methanone

HRID 1294870Notes

Reaction equation

HRID 1294870 reaction equation
[F:1][C:2]1[C:13]([CH3:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[Mg]Br>>[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[C:4]([C:3]1[CH:10]=[CH:11][CH:12]=[C:13]([CH3:14])[C:2]=1[F:1])=[O:5]

Participants

3

Reactant 2

HCID 807180582-fluoro-N-methoxy-N,3-dimethylbenzamideHCID 178491918HCID 178491918, compound

Product 1

HCID 68883155(2,4-Dimethoxyphenyl)(2-fluoro-3-methylphenyl)methanone

Procedure

Prepared according to Method A step B from 2-fluoro-3-methyl-N-methoxy-N-methyl-benzamide (2.84 g, 14.4 mmol) and 2,4-dimethoxyphenylmagnesium bromide (26 mL, 0.5 M in THF) to give 1.13 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-130ef89977f74e28960bbc1fc52d1216
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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