2,3-difluoro-N-methoxy-N-methylbenzamide → (2,3-Difluorophenyl)(2,4-dimethoxyphenyl)methanone

HRID 1294873Notes

Reaction equation

HRID 1294873 reaction equation
[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4](N(OC)C)=[O:5].[CH3:15][O:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[Mg]Br>>[F:1][C:2]1[C:13]([F:14])=[CH:12][CH:11]=[CH:10][C:3]=1[C:4]([C:20]1[CH:19]=[CH:18][C:17]([O:16][CH3:15])=[CH:22][C:21]=1[O:23][CH3:24])=[O:5]

Participants

3

Reactant 2

HCID 626611902,3-difluoro-N-methoxy-N-methylbenzamideHCID 178491918HCID 178491918, compound

Product 1

HCID 67021364(2,3-Difluorophenyl)(2,4-dimethoxyphenyl)methanone

Procedure

Prepared according to Method A step B from 2,3-difluoro-N-methoxy-N-methyl-benzamide (3.22 g, 16.0 mmol) and 2,4-dimethoxyphenylmagnesium bromide (29 mL, 0.5 M in THF) to give 1.21 g of the title compound as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-95c453c2cdbd47ac827e68818935c91f
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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