2,2',4,4'-Tetrahydroxybenzophenone → 680610-81-5

HRID 1294881Notes

Reaction equation

HRID 1294881 reaction equation
O[C:2]1[CH:17]=[C:16]([OH:18])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[OH:13])=O.C([O-])(=O)C.[Na+].Cl.[Cl:25][C:26]1[CH:27]=[C:28]([NH:32][NH2:33])[CH:29]=[CH:30][CH:31]=1>>[Cl:25][C:26]1[CH:27]=[C:28]([N:32]2[C:2]3[C:3](=[CH:14][CH:15]=[C:16]([OH:18])[CH:17]=3)[C:4]([C:6]3[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=3[OH:13])=[N:33]2)[CH:29]=[CH:30][CH:31]=1

Participants

4

Reactant 3

HCID 85712,2',4,4'-TetrahydroxybenzophenoneHCID 75331m-Chlorophenylhydrazine hydrochlorideHCID 517045Sodium Acetate

Product 1

HCID 135500018680610-81-5Yield 87.9%

Procedure

Prepared according to Method B from 2,2′,4,4′-tetrahydroxybenzophenone (2.46 g, 10 mmol), sodium acetate (0.82 g, 10 mmol) and 3-chlorophenylhydrazine hydrochloride (1.97 g, 11 mmol) to give 3.1 g of product as a tan solid Crystallized from EtOAc/hexane to give 1.4 g of an off-white solid (mp 228–230° C.).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-10f5f5b068b14578af78690b9b1ebb63
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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