2,2',4,4'-Tetrahydroxybenzophenone → 4-[6-Hydroxy-1-(4-nitrophenyl)-1h-indazol-3-yl]benzene-1,3-diol

HRID 1294896Notes

Reaction equation

HRID 1294896 reaction equation
O[C:2]1[CH:17]=[C:16]([OH:18])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=1[OH:13])=O.C([O-])(=O)C.[Na+].Cl.[N+:25]([C:28]1[CH:33]=[CH:32][C:31]([NH:34][NH2:35])=[CH:30][CH:29]=1)([O-:27])=[O:26]>>[OH:18][C:16]1[CH:17]=[C:2]2[C:3]([C:4]([C:6]3[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][C:7]=3[OH:13])=[N:35][N:34]2[C:31]2[CH:32]=[CH:33][C:28]([N+:25]([O-:27])=[O:26])=[CH:29][CH:30]=2)=[CH:14][CH:15]=1

Participants

4

Reactant 3

HCID 85712,2',4,4'-TetrahydroxybenzophenoneHCID 517045Sodium AcetateHCID 54634014-Nitrophenylhydrazine hydrochloride

Product 1

HCID 1364095894-[6-Hydroxy-1-(4-nitrophenyl)-1h-indazol-3-yl]benzene-1,3-diolYield 17.4%

Procedure

Prepared according to Method B from 2,2′,4,4′-tetrahydroxybenzophenone (0.400 g, 1.60 mmol), sodium acetate (0.267 g, 3.3 mmol) and 4-nitrophenylhydrazine hydrochloride (0.463 g, 2.5 mmol) to give 0.101 g of product as a pink solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d6a61c89e8804504acb01d8f3622f18d
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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