Cyclohexene → 4-(1-isopropyl-7-methyl-1H-indazol-3-yl)phenol

HRID 1294924Notes

Reaction equation

HRID 1294924 reaction equation
[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[C:6]([C:14]2[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][CH:15]=2)=[N:5]1)([CH3:3])[CH3:2].B(Br)(Br)Br.C1CCCCC=1>>[CH:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[CH3:13])[C:6]([C:14]2[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=2)=[N:5]1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688843421-isopropyl-3-(4-methoxyphenyl)-7-methyl-1H-indazole

Product 1

HCID 1354381754-(1-isopropyl-7-methyl-1H-indazol-3-yl)phenolYield 50.7%

Procedure

Prepared according to Method D step C from 1-isopropyl-3-(4-methoxyphenyl)-7-methyl-1H-indazole (0.057 g, 0.20 mmol), boron tribromide (0.094 mL, 1.0 mmol) and 0.3 mL of cyclohexene to give the product (0.027 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-6b7b2001946b4c35b4ac8d8644184576
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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