Cyclohexene → 4-[7-chloro-2-pentyl-2H-indazol-3-yl]phenol

HRID 1294930Notes

Reaction equation

HRID 1294930 reaction equation
[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:16]3[CH:21]=[CH:20][C:19]([O:22]C)=[CH:18][CH:17]=3)[N:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:9]=2)[CH:5]=[CH:4][CH:3]=1.B(Br)(Br)Br.C1CCCCC=1>>[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:16]3[CH:17]=[CH:18][C:19]([OH:22])=[CH:20][CH:21]=3)[N:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688859867-chloro-3-(4-methoxyphenyl)-2-pentyl-2H-indazole

Product 1

HCID 1355119114-[7-chloro-2-pentyl-2H-indazol-3-yl]phenolYield 49.4%

Procedure

Prepared according to Method D step C from 7-chloro-3-(4-methoxyphenyl)-2-pentyl-2H-indazole (0.015 g, 0.045 mmol), boron tribromide (0.05 mL, 0.5 mmol) and 0.2 mL of cyclohexene to give the product (0.007 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3ff4a47c9d814b1dbaff72652e2ecec5
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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