Cyclohexene → 4-[7-chloro-2-propyl-2H-indazol-3-yl]phenol

HRID 1294933Notes

Reaction equation

HRID 1294933 reaction equation
[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:14]3[CH:19]=[CH:18][C:17]([O:20]C)=[CH:16][CH:15]=3)[N:8]([CH2:11][CH2:12][CH3:13])[N:9]=2)[CH:5]=[CH:4][CH:3]=1.B(Br)(Br)Br.C1CCCCC=1>>[Cl:1][C:2]1[C:10]2[C:6](=[C:7]([C:14]3[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=3)[N:8]([CH2:11][CH2:12][CH3:13])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 688824767-chloro-3-(4-methoxyphenyl)-2-propyl-2H-indazole

Product 1

HCID 1355035854-[7-chloro-2-propyl-2H-indazol-3-yl]phenolYield 56.8%

Procedure

Prepared according to Method D step C from 7-chloro-3-(4-methoxyphenyl)-2-propyl-2H-indazole (0.013 g, 0.043 mmol), boron tribromide (0.05 mL, 0.5 mmol) and 0.2 mL of cyclohexene to give the product (0.007 g).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9ef53ce3c6e341bcabf4b9ce19645f3e
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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