Cyclohexene → HCID 136358441, compound

HRID 1294949Notes

Reaction equation

HRID 1294949 reaction equation
[CH2:1]([N:4]1[C:12]2[C:7](=[C:8](C)[CH:9]=[CH:10][C:11]=2[F:13])[C:6]([C:15]2[CH:20]=[CH:19][C:18]([O:21]C)=[CH:17][CH:16]=2)=[N:5]1)[CH2:2][CH3:3].B(Br)(Br)Br.C1CCCCC=1>>[F:13][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[N:4]([CH2:1][CH2:2][CH3:3])[N:5]=[C:6]2[C:15]1[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68885245HCID 68885245, compound

Product 1

HCID 136358441HCID 136358441, compoundYield 95.8%

Procedure

Prepared according to Method D step C from 1-propyl-7-fluoro-3-(4-methoxyphenyl)-methyl-1H-indazole (0.051 g, 0.197 mmol), boron tribromide (0.10 mL, 1.05 mmol) and 0.3 mL of cyclohexene to give the product (0.051 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-81c32e02c34a4f7a839748fb4b888564
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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