Cyclohexene → 4-(2-cyclopentyl-7-fluoro-2H-indazol-3-yl)phenol

HRID 1294965Notes

Reaction equation

HRID 1294965 reaction equation
[CH:1]1([N:6]2[C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21]C)=[CH:17][CH:16]=3)=[C:13]3[C:8]([C:9]([F:23])=[CH:10][CH:11]=[CH:12]3)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:6]2[C:14]([C:15]3[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=3)=[C:13]3[C:8]([C:9]([F:23])=[CH:10][CH:11]=[CH:12]3)=[N:7]2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 115005622-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-2H-indazole

Product 1

HCID 1354539644-(2-cyclopentyl-7-fluoro-2H-indazol-3-yl)phenolYield 57.2%

Procedure

Prepared according to Method D step C from 2-cyclopentyl-7-fluoro-3-(4-methoxyphenyl)-2H-indazole (0.055 g, 0.177 mmol), boron tribromide (0. 70 mL, 0.74 mmol) and 0.3 mL of cyclohexene to give the product (0.03 g) as an amber solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0c12765c11cd476cb810858deef8b372
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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