Cyclohexene → HCID 136358446, compound

HRID 1294971Notes

Reaction equation

HRID 1294971 reaction equation
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[C:15]([F:18])([F:17])[F:16])[C:8]([C:19]3[CH:24]=[CH:23][C:22]([O:25]C)=[CH:21][C:20]=3[O:27]C)=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][C:13]=3[C:15]([F:18])([F:16])[F:17])[C:8]([C:19]3[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][C:20]=3[OH:27])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68882428HCID 68882428, compound

Product 1

HCID 136358446HCID 136358446, compoundYield 97.5%

Procedure

Prepared according to Method D step C from 1-cyclopentyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole (0.465 g, 1.2 mmol), boron tribromide (0.67 mL, 7.1 mmol) and 1.0 mL of cyclohexene to give the product (0.424 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d7df576df87a42689b2038056e48635a
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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