Cyclohexene → HCID 136358447, compound

HRID 1294972Notes

Reaction equation

HRID 1294972 reaction equation
[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[C:17]([F:20])([F:19])[F:18])[C:10]([C:21]3[CH:26]=[CH:25][C:24]([O:27]C)=[CH:23][C:22]=3[O:29]C)=[N:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][C:15]=3[C:17]([F:20])([F:19])[F:18])[C:10]([C:21]3[CH:26]=[CH:25][C:24]([OH:27])=[CH:23][C:22]=3[OH:29])=[N:9]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68882811HCID 68882811, compound

Product 1

HCID 136358447HCID 136358447, compoundYield 72.6%

Procedure

Prepared according to Method D step C from 1-(cyclohexylmethyl)-3-(2,4-dimethoxy-phenyl)-7-(trifluoromethyl)-1H-indazole (0.841 g, 2.0 mmol), boron tribromide (1.14 mL, 12 mmol) and 0.5 mL of cyclohexene to give the product (0.567 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-384b7f27c7a147a5b3acb496c112856f
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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