Cyclohexene → HCID 135566806, compound

HRID 1294973Notes

Reaction equation

HRID 1294973 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([O:9]C)[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:24][CH:25]([CH3:27])[CH3:26])[N:12]=1.B(Br)(Br)Br.C1CCCCC=1>>[CH2:24]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])[C:11]([C:4]2[CH:5]=[CH:6][C:7]([OH:9])=[CH:8][C:3]=2[OH:2])=[N:12]1)[CH:25]([CH3:27])[CH3:26]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68882579HCID 68882579, compound

Product 1

HCID 135566806HCID 135566806, compoundYield 49.5%

Procedure

Prepared according to Method D step C from 3-(2,4-dimethoxyphenyl)-1-isobutyl-7-(trifluoromethyl)-1H-indazole (0.675 g, 1.2 mmol), boron tribromide (1.01 mL, 10.7 mmol) and 1.0 mL of cyclohexene to give the product (0.208 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d9864a448f18435fa266be70b456f2a2
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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