Cyclohexene → HCID 136358449, compound

HRID 1294975Notes

Reaction equation

HRID 1294975 reaction equation
[CH:1]1([N:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][C:12]=3[C:14]([F:17])([F:16])[F:15])[C:7]([C:18]3[CH:23]=[CH:22][C:21]([O:24]C)=[CH:20][C:19]=3[O:26]C)=[N:6]2)[CH2:4][CH2:3][CH2:2]1.B(Br)(Br)Br.C1CCCCC=1>>[CH:1]1([N:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][C:12]=3[C:14]([F:15])([F:16])[F:17])[C:7]([C:18]3[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][C:19]=3[OH:26])=[N:6]2)[CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68882004HCID 68882004, compound

Product 1

HCID 136358449HCID 136358449, compoundYield 41%

Procedure

Prepared according to Method D step C from 1-cyclobutyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-1H-indazole (0.575 g, 1.5 mmol), boron tribromide (0.866 mL, 9.1 mmol) and 0.5 mL of cyclohexene to give the product (0.214 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-40c4df8798bd43e29717fdbbaa0bde3c
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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