Cyclohexene → HCID 136358450, compound

HRID 1294976Notes

Reaction equation

HRID 1294976 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([O:9]C)[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([C:20]([F:23])([F:22])[F:21])[CH:16]=[CH:17][CH:18]=2)[N:13]([CH:24]([CH2:27][CH3:28])[CH2:25][CH3:26])[N:12]=1.B(Br)(Br)Br.C1CCCCC=1>>[CH2:25]([CH:24]([N:13]1[C:14]2[C:19](=[CH:18][CH:17]=[CH:16][C:15]=2[C:20]([F:23])([F:22])[F:21])[C:11]([C:4]2[CH:5]=[CH:6][C:7]([OH:9])=[CH:8][C:3]=2[OH:2])=[N:12]1)[CH2:27][CH3:28])[CH3:26]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68884733HCID 68884733, compound

Product 1

HCID 136358450HCID 136358450, compoundYield 70.9%

Procedure

Prepared according to Method D step C from 3-(2,4-dimethoxyphenyl)-1-(1-ethylpropyl)-7-(trifluoromethyl)-1H-indazole (0.557 g, 1.42 mmol), boron tribromide (0.81 mL, 8.51 mmol) and 0.5 mL of cyclohexene to give the product (0.367 g) as an off-white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7f91781ddd6b4824834db4aeb59749d7
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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