Cyclohexene → 4-[2-allyl-7-(trifluoromethyl)-2H-indazol-3-yl]-1,3-benzenediol

HRID 1294984Notes

Reaction equation

HRID 1294984 reaction equation
[CH2:1]([N:4]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][C:14]=2[O:21]C)=[C:11]2[C:6]([C:7]([C:23]([F:26])([F:25])[F:24])=[CH:8][CH:9]=[CH:10]2)=[N:5]1)[CH:2]=[CH2:3].B(Br)(Br)Br.C1CCCCC=1>>[CH2:1]([N:4]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][C:14]=2[OH:21])=[C:11]2[C:6]([C:7]([C:23]([F:26])([F:25])[F:24])=[CH:8][CH:9]=[CH:10]2)=[N:5]1)[CH:2]=[CH2:3]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 57890016HCID 57890016, compound

Product 1

HCID 1355119484-[2-allyl-7-(trifluoromethyl)-2H-indazol-3-yl]-1,3-benzenediolYield 40.6%

Procedure

Prepared according to Method D step C from 2-allyl-3-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)-2H-indazole (0.05 g, 0.14 mmol), boron tribromide (0.104 mL, 1.1 mmol) and 1.0 mL of cyclohexene to give the product (0.019 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-63e97f08f04e4533810c45f86fdb1786
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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