Cyclohexene → HCID 136358466, compound

HRID 1295016Notes

Reaction equation

HRID 1295016 reaction equation
C[O:2][C:3]1[CH:8]=[C:7]([O:9]C)[CH:6]=[CH:5][C:4]=1[C:11]1[C:19]2[C:14](=[C:15]([F:20])[CH:16]=[CH:17][CH:18]=2)[N:13]([CH2:21][CH:22]([CH3:24])[CH3:23])[N:12]=1.B(Br)(Br)Br.C1CCCCC=1>>[F:20][C:15]1[CH:16]=[CH:17][CH:18]=[C:19]2[C:14]=1[N:13]([CH2:21][CH:22]([CH3:24])[CH3:23])[N:12]=[C:11]2[C:4]1[CH:5]=[CH:6][C:7]([OH:9])=[CH:8][C:3]=1[OH:2]

Participants

4

Reactant 3

HCID 8079CyclohexeneHCID 25134Boron tribromideHCID 68883805HCID 68883805, compound

Product 1

HCID 136358466HCID 136358466, compoundYield 56.6%

Procedure

Prepared according to Method D step C from 3-(2,4-dimethoxyphenyl)-7-fluoro-1-isobutyl-1H-indazole (0.177 g, 0.5 mmol), boron tribromide (0.275 mL, 2.90 mmol) and 1.0 mL of cyclohexene to give the product (0.085 g) as a white solid.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-36e6f92fb7954ca294c67219e5767485
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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