Boron tribromide → HCID 136367441, compound

HRID 1295039Notes

Reaction equation

HRID 1295039 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][CH3:13])[N:8]=[C:7]2[C:14]1[CH:19]=[CH:18][C:17]([O:20]C)=[C:16]([F:22])[CH:15]=1.B(Br)(Br)Br>>[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[N:9]([CH2:11][CH2:12][CH3:13])[N:8]=[C:7]2[C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[C:16]([F:22])[CH:15]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 68884326HCID 68884326, compound

Product 1

HCID 136367441HCID 136367441, compoundYield 48%

Procedure

Prepared according to Method D step C from 7-Chloro-3-(3-fluoro-4-methoxyphenyl)-1-propyl-1H-indazole (0.26 g, 0.82 mmol), BBr3 (0.15 mL, 1.63 mmol) to give the title compound as a white solid (0.12 g, 0.39 mmol, 48%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-89ba2c20755b4016aa645ee37b5623f0
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

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