Boron tribromide → HCID 136358476, compound

HRID 1295042Notes

Reaction equation

HRID 1295042 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[C:18]3[C:13](=[C:14]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:15]=[CH:16][CH:17]=3)[N:12]([CH2:25][CH2:26][CH3:27])[N:11]=2)[CH:5]=[CH:6][C:7]=1[O:8]C.B(Br)(Br)Br>>[F:1][C:2]1[CH:3]=[C:4]([C:10]2[C:18]3[C:13](=[C:14]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:15]=[CH:16][CH:17]=3)[N:12]([CH2:25][CH2:26][CH3:27])[N:11]=2)[CH:5]=[CH:6][C:7]=1[OH:8]

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 68883745HCID 68883745, compound

Product 1

HCID 136358476HCID 136358476, compoundYield 58%

Procedure

Prepared according to Method D step C from 3-(3-Fluoro-4-methoxyphenyl)-7-phenyl-1-propyl-1H-indazole (0.28 g, 0.78 mmol), BBr3 (0.073 mL, 0.78 mmol) gave title compound as a white solid (0.156 g, 0.45 mmol, 58%).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-202471e16e3a4de99313f042320e8fdf
Source dataset
uspto-grants-2007_07
Patent number
US07241791B2

Reaction notes

Loading…