HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isocyanate → 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenyl ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isocyanate | HCID 8022 | — |
| Reactant | 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol | HCID 135524867 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenyl ethylcarbamate | HCID 68882957 | 74.8% |
Reaction Steps
A solution of 4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol (0.30 g, 1.0 mmol) and ethyl isocyanate (0.080 mL, 1.0 mmol) in 10 mL of dioxane was heated at 80° C. for 48 hours. The reaction mixture was concentrated in vacuo. The residue was crystallized from EtOAc/hexane to give 0.275 g of the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241791B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-df1045168c6d43668ed8792b2321cbe1 |
| Source note | uspto-grants-2007_07 |