反应详情

温度

80 °C

20 ml of methanol, 10 ml of water and 1 g of sodium hydroxide were added to 0.9 g of ethyl 4-tetrahydropyranylacetate and agitated at 80° C. for 1 hour. The solvent was removed by distillation, to which water was added. After washing with ethyl acetate, a hydrochloric acid aqueous solution was added to the resultant aqueous phase to an extent of pH of 3, followed by extraction with chloroform under salting-out conditions and drying with anhydrous magnesium sulfate. This was removed by filtration and the solvent was distilled off, thereby obtaining 0.87 g of a crude intended compound.

1. customThe solvent was removed by distillation, to which water
2. additionwas added
3. washAfter washing with ethyl acetate
4. additiona hydrochloric acid aqueous solution was added to the resultant aqueous phase to an extent of pH of 3
5. extractionfollowed by extraction with chloroform under salting-out conditions
6. dry with materialdrying with anhydrous magnesium sulfate
7. customThis was removed by filtration
8. distillationthe solvent was distilled off
9. customobtaining 0.87 g of a crude intended compound