Methyl morpholine oxide → HCID 69064365, compound

Participants

Reaction Steps

To a solution of 6-cyclopropylmethyl-bicyclo[3.1.0]hexan-2-ol (220 mg, 1.45 mmol) in 10 mL DCM was added sequentially 4 A Molecular sieves (200 mg), NMO (N-Methyl morpholine N-oxide) (339 mg, 2.90 mmol), TPAP label (25.448 mg, 0.0725 mmol). The mixture was stirred overnight at room temperature and plugged through silica gel (3:1 DCM: Et2O) to give 6-cyclopropylmethyl-bicyclo[3.1.0]hexan-2-one as a clear oil; 1H NMR (400 MHz, CDCl3): δ 2.32–2.21 (m, 2H), 2.16 (dd, 1H, J1=13.4 Hz, J2=5.4 Hz), 1.97–1.86 (m, 3H), 1.61–1.53 (m, 1H), 1.38–1.28 (m, 2H), 0.82–0.73 (m, 1H), 0.49–0.44 (m, 2H), 0.09–0.05 (m, 2H).

Provenance & Evidence