Sodium Hydroxide → HCID 58906999, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of example 90 (780 mg, 1.32 mmol) in EtOH (20 mL) was added 1N NaOH (4 mL, 3 eq.) and the reaction was stirred at 80° C. for 2h. When all of the starting material had disappeared, the reaction cooled, evaporated to dryness, taken up with 1N HCl, extracted with CH2Cl2 and the organic phase washed with water. The organic layer was then dried over Na2SO4, filtered and the solvent removed in vacuo. The residue was chromatographed eluting with CH2Cl2 (100%) then CH2Cl2/MeOH (90/10) to afford the title compound as a yellow solid (410 mg, 55.4%).

Provenance & Evidence