Sodium Hydroxide → HCID 58906942, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of example 96 (450 mg, 0.29 mmol) in EtOH (20 mL) was added 1N NaOH (0.9 mL, 3 eq.) and the reaction was stirred at 85° C. for 1 h. When all of the starting material had disappeared, the reaction cooled, evaporated to dryness, taken up with 1N HCl, extracted with CH2Cl2 and washed with water. The organic phase was dried over Na2SO4, filtered and the solvent removed in vacuo. The residue was chromatographed eluting with CH2Cl2 (100%) to afford the title compound as a yellow solid (60 mg, 34%).

Provenance & Evidence