Hydrochloric Acid → HCID 69428124, compound

Participants

Reaction Steps

A mixture of methyl [4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]phenyl]acetate (1.00 g), methyl 4-hydroxy-5-oxo-5-phenylpentanoate (709 mg), WSC (734 mg), 4-(N,N-dimethylamino)pyridine (77.9 mg) and N,N-dimethylformamide (10 ml) was stirred at room temperature for 6 hrs. The reaction mixture was poured into 1N hydrochloric acid and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated. The residue was subjected to silica gel column chromatography, and methyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]phenyl]acetoxy-5-oxo-5-phenylpentanoate (1.56 g, yield %) was obtained as a pale-yellow oil from a fraction eluted with ethyl acetate-hexane (2:3, volume ratio).

Provenance & Evidence