反应详情

A mixture of methyl 4-bromo-5-oxo-5-phenylpentanoate (5.00 g), N-propylthiourea (2.01 g) and methanol (50 ml) was refluxed for 2 hrs. The reaction solvent was removed under reduced pressure, and the residue was dissolved in ethyl acetate. The obtained solution was washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give methyl 3-[4-phenyl-2-[N-(1-propyl)amino]-5-thiazolyl]propionate (3.64 g, yield 70%) as colorless crystals. The crystals were recrystallized from ethyl acetate-hexane. melting point: 67–68° C.

1. temperaturewas refluxed for 2 hrs
2. customThe reaction solvent was removed under reduced pressure
3. dissolutionthe residue was dissolved in ethyl acetate
4. washThe obtained solution was washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine
5. dry with materialdried over anhydrous magnesium sulfate
6. concentrationconcentrated