反应详情

温度

55 °C

To a solution of 7.6 g (30 mmol) of methyl 3-cyclododecylpropanoate in 100 ml of methanol is added 2.4 g of sodium hydroxide. The mixture is heated to 55° C. and is maintained for 4 hours. The reaction mixture is diluted with water and is extracted with hexane. The aqueous phase is acidified with 1N hydrochloric acid and is extracted (2 times) with ethyl ether. The combined ethereal extracts are washed with 1N hydrochloric acid and are dried over magnesium sulfate. Filtration and evaporation gives 7.48 g of crude title compound. Recrystallization of a portion of the product from hexane gives 1.81 g of the title compound: m.p. 72°-74° C.; IR (KBr) 1715 cm-1 ; NMR (CDCl3) δ 1.34 (m, 23 H), 1.57 (q, 2 H, J=8 Hz), 2.36 (t, 2 H, J=8 Hz).

1. temperatureis maintained for 4 hours
2. extractionis extracted with hexane
3. extractionis extracted (2 times) with ethyl ether
4. washThe combined ethereal extracts are washed with 1N hydrochloric acid
5. dry with materialare dried over magnesium sulfate
6. filtrationFiltration and evaporation
7. customgives 7.48 g of crude title compound
8. customRecrystallization of a portion of the product from hexane