Hydrochloric Acid → HCID 69427774, compound

Participants

Reaction Steps

A mixture of ethyl [2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenylthio]-4-thiazolylacetate (330 mg), lithium hydroxide hydrate (89.0 mg), tetrahydrofuran (3 ml), water (2 ml) and methanol (2 ml) was stirred at room temperature for 4 hrs. 1N Hydrochloric acid (2.2 ml) was added to the reaction mixture and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated brine, dried (MgSO4) and concentrated to give [2-[4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenylthio]-4-thiazolyl]acetic acid (215 mg, yield 69%) as colorless crystals. The crystals were recrystallized from ethyl acetate-hexane. melting point: 180–181° C.

Provenance & Evidence