Hydrochloric Acid → HCID 69433064, compound

Participants

Reaction Steps

The HCl salt of the starting material Intermediate 28, mixture of diastereomers (1R,2S)-3-Benzyl-2-phenyl-3-aza-bicyclo[3.1.0]hexan-1-ol (1.2 g, 4.1 mmol), was combined with palladium on carbon 20% (Pearlman's catalyst, 0.7 g) and MeOH (35 mL) and hydrogenated at 40 psi for 16 hours. The material was filtered thru celite and concentrated to yield the title compounds as a mixture of diastereomers (0.88 g, quantitative yield).

Provenance & Evidence