Thionyl Chloride → HCID 86602055, compound

Participants

Reaction Steps

To racemic Intermediate 39, one enantiomer being (1S,2S)-3-benzyl-2-phenyl-3-aza-bicyclo[3.1.0]hexane-1-carboxylic acid (0.16 g, 0.56 mmol) was added thionyl chloride (2 mL) dropwise with stirring. The homogeneous solution was refluxed gently for 2 hours. The solvent was removed at reduced pressure to yield the title compound (0.17 g, quantitative yield) as an oil, which was used without further purification.

Provenance & Evidence