Trifluoroacetic acid → HCID 86602062, compound

Participants

Reaction Steps

A flask containing Intermediate 50, a mixture of four isomers, one being ((1S,2S)-3-{[(S)-1-(3,5-bis-trifluoromethyl-phenyl)-ethyl]-methyl-carbamoyl}-2-phenyl-3-aza-bicyclo[3.1.0]hex-1-yl)-methyl-carbamic acid tert-butyl ester (0.17 g, 0.30 mmol), and methylene chloride (5 mL) was immersed in a 0° C. bath. Trifluoroacetic acid (0.46 mL, 6.0 mmol) was added, and the reaction stirred for 16 hours at room temperature. The solvent was removed at reduced pressure and the residue partitioned between saturated sodium bicarbonate solution and methylene chloride, the organics were washed with brine, dried over sodium sulfate, filtered, and concentrated to give the title compound as an oil (0.15 g, quantitative yield).

Provenance & Evidence