HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetate → HCID 69511683, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Reactant | D-aspartic acid di-t-butyl ester | HCID 7269469 | — |
| Reactant | N-(4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenyl)acetamide | HCID 9902940 | — |
| Product | HCID 69511683 | HCID 69511683 | — |
Reaction Steps
300 mg (0.9 mmol) of 3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzoic acid (Example 14, intermediate 5) were reacted in a similar manner to the method described in Example 14 with 304 mg (1.0 mmol) of di-tert-butyl aspartate in a TOTU-mediated coupling reaction to obtain 170 mg of the title compound as the trifluoroacetate after purification on a preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07241775B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-f880502db3a94d78accc02d72af65919 |
| Source note | uspto-grants-2007_07 |