Acetonitrile → Ethyl {3-[4-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)-phenyl]ureido}acetate hydrochloride
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16](NC(NC(CO)CO)=O)[CH:17]=[CH:18][CH:19]=1.[N:29]([CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])=[C:30]=[O:31].C(#[N:40])C>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][C:17]([NH:40][C:30](=[O:31])[NH:29][CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])=[CH:16][CH:15]=1Participants
4
Reactant 3
Product 1
Procedure
4-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)phenylamine (95 mg, example 1, intermediate 6) was dissolved in acetonitrile (2 ml) and ethyl isocyanatoacetate (30 mg) was added dropwise with stirring. After four hours, the solution was concentrated and the residue purified by means of preparative HPLC. The product-containing fractions were combined, the acetonitrile was removed on a rotary evaporator, and the aqueous residue was neutralized with potassium carbonate and extracted three times with ethyl acetate. Drying over magnesium sulfate was followed by drying. The residue was taken up with aqueous hydrochloric acid and freeze-dried. 107 mg of the desired compound were obtained.
Workup
- concentrationthe solution was concentrated
- customthe residue purified by means of preparative HPLC
- customthe acetonitrile was removed on a rotary evaporator
- extractionextracted three times with ethyl acetate
- dry with materialDrying over magnesium sulfate
- customby drying
- customfreeze-dried
Sources & evidence
- ORD record
- ord-6bbfff92812e4451ba294992c78698ab
- Source dataset
- uspto-grants-2007_07
- Patent number
- US07241775B2
Reaction notes
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