Ethyl isocyanatoacetate → HCID 86760511, compound

HRID 1295440Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21](=[O:32])[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.[N:33]([CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38])=C=O>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21](=[O:32])[NH:33][CH2:36][C:37]([O:39][CH2:40][CH3:41])=[O:38]

Participants

Reactant 2

HCID 76283Ethyl isocyanatoacetate

HCID 11488611HCID 11488611, compound2×

Product 1

HCID 86760511HCID 86760511, compound

Procedure

In a similar manner to example 34, 2-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)phenylamine (example 3, intermediate 5) and ethyl isocyanatoacetate were reacted.

Sources & evidence

ORD record: ord-4c776022052d4c94ae604e48b9a0bfda
Source dataset: uspto-grants-2007_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07241775B2

Reaction notes

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