HCID 86760513, compound → HCID 86760512, compound

Participants

Reaction Steps

Ethyl (2S)-3-[4-(2-{[(benzyloxy)carbonyl]amino}ethyl)phenyl]-2-ethoxypropanoate (2.45 g, 6.14 mmol) was hydrogenated for 2.5 hours at atmospheric pressure in ethyl acetate (51 ml) using Pd/C (1 spoon) as catalyst. After filtration on hyflo, the solvent was evaporated in vacuo. The crude product was purified by chromatography on silica gel using THF:methanol (NH3-saturated) (gradient 25:1–1:25) as eluent. The first fractions containing the product was filtered on Millipore filter and combined with the later fractions containing product to give 0.84 g (yield 52%, including a by-product) of the desired product.

Provenance & Evidence