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HRID1295516

反应详情

EQUATION

反应方程式

HRID 1295516 反应方程式

REACTANTS

反应物

5
Carbamic acid, ion(1-) 分子结构式
HCID276

Carbamic acid, ion(1-)

CH2NO2-

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) 分子结构式
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

N-[tert-Butoxy(hydroxy)methylidene]-2-methylserine 分子结构式
HCID12991620

N-[tert-Butoxy(hydroxy)methylidene]-2-methylserine

C9H17NO5

HCID 69114209 分子结构式
HCID69114209

未命名化合物

HCID 86605703 分子结构式
HCID86605703

未命名化合物

PRODUCTS

产物

1
HCID 86605702 分子结构式
HCID86605702

未命名化合物

收率 47.9%

AUXILIARIES

试剂、催化剂与溶剂

1
Diisopropylethylamine 分子结构式
溶剂HCID81531

Diisopropylethylamine

C8H19N

PROCEDURE

实验过程

1-(3-(trifluoromethyl)phenethyloxy)-4-nitrobenzene (470 mg) was converted to 290 mg tert-butyl (S)-2-(4-(3-(trifluoromethyl)phenethyloxy)phenylcarbamoyl)-1-hydroxypropan-2-ylcarbamate following the general procedure provided in Example 5(A) employing N-(Boc)-α-methylserine (210 mg), HATU (360 mg), and DIPEA (900 μl). MS (ESI, M+H+)=483.4. The carbamate (145 mg) was deprotected following the procedure in Example 5(A) yielding 143 mg of the title compound. MS (ESI, M+H+)=383.1. 1H NMR (400 MHz, DMSO-d6) δ 9.8 (bs, 1H), 7.67–7.40 (m, 6H), 6.88 (m, 2H), 5.67 (bs, 1H), 4.18 (t, 3H), 3.91 (m, 1H), 3.58 (m, 1H), 3.11 (t, 3H), 1.41 (s, 3H).

WORKUP

后处理

  1. customprovided in Example 5(A)