Ammonia → HCID 23073050, compound

Participants

Reaction Steps

The aforementioned 5-(RS)-methyl-5-(3-indolylmethyl)-4,5-dihydroisoxazole-3-carboxylic acid in an amount of 540 mg was dissolved in 4 ml of ethanol, and 10 ml of 28% aqueous ammonia and 300 mg of 5% Rh—C were added thereto. Reduction performed at room temperature in an atmosphere of hydrogen at 10 atm for 12 hrs. The catalyst was removed by filtration, and after vacuum concentrating the filtrate, the product was again dissolved in water followed by freeze-drying resulting in 370 mg of 2-amino-4-hydroxy-4-(3-indolylmethyl)pentanoic acid (1.41 mmol) as light brown powder (Compound No. 5 in Table 1).

Provenance & Evidence