Ammonium Hydroxide → HCID 11174185, compound

Participants

Reaction Steps

The title compound from Example 2 (0.040 g, 0.0132 mmol) was dissolved in methanol and NH4OH was added and the mixture left at ambient temperature for 1 hour. The solvent was evaporated, the residue dissolved in methanol and co-evaporated with silica gel. Dry silica was loaded on the glass filter with silica gel and the desilylated compound was eluted with acetone. Solvent was evaporated and the residue crystallized from methanol/acetonitrile to provide for 7-(2′-C-methyl-β-D-ribofuranosyl)-4-amino-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine.

Provenance & Evidence