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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 129556Generated: October 28, 2026

Piperidin-4-ol → 6-Chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-7-(4-hydroxy-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acid

https://huagongshe.com/reaction/129556

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidin-4-olHCID 79341—
Reactant6-Chloro-1-cyclopropyl-7,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acidHCID 13579163—
Product6-Chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-7-(4-hydroxy-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acidHCID 13579179—

Reaction Steps

When the product from Example A is reacted with 4-hydroxypiperidine in analogy to Example 17, then 6-chloro-1-cyclopropyl-8-fluoro-1,4-dihydro-7-(4-hydroxy-1-piperidinyl)-4-oxo-3-quinolinecarboxylic acid of melting point 226°-221° (with decomposition) is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05468861
Source datasetuspto-grants-1995_11
ORD IDord-83e06a1d203e4760b6ad70b996bbfb6f
Source noteuspto-grants-1995_11