Trifluoroacetic acid → 7-(Piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one

HRID 1295562Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1295562
[O:1]=[C:2]1[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][C:6]([O:12][CH:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)=[CH:7][CH:8]=2)[NH:3]1.FC(F)(F)C(O)=O>ClCCl>[NH:16]1[CH2:15][CH2:14][CH:13]([O:12][C:6]2[CH:5]=[C:4]3[C:9]([CH2:10][CH2:11][C:2](=[O:1])[NH:3]3)=[CH:8][CH:7]=2)[CH2:18][CH2:17]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 57575910tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)piperidine-1-carboxylate

Produkt 1

HCID 179651447-(Piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)piperidine-1-carboxylate (0.2 g, 0.58 mmol) was dissolved in dichloromethane (20 mL) and treated with trifluoroacetic acid (1.3 mL). The resulting mixture was stirred at ambient temperature until all the starting material had been consumed, at which time the volatiles were removed by evaporation to dryness under reduced pressure. The residue was neutralized by addition of excess saturated NaHCO3 aq. and the mixture evaporated to dryness under reduced pressure.

Aufarbeitung

  1. customhad been consumed, at which time the volatiles
  2. customwere removed by evaporation to dryness under reduced pressure
  3. additionThe residue was neutralized by addition of excess saturated NaHCO3 aq.
  4. customthe mixture evaporated to dryness under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-6adad88f415540618c81179065141ee0
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07244726B2

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