2-Amino-6-fluorobenzylamine → HCID 178432155, compound

HRID 1295563Notes

Reaction equation

HRID 1295563 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([F:10])[C:3]=1[CH2:4][NH2:5].[CH2:11](C(CC)(CC)C([O-])([O-])[O-])[CH3:12]>C(O)C>[F:10][C:6]1[CH:7]=[CH:8][CH:9]=[C:2]2[C:3]=1[CH2:4][NH:5][C:11]([CH3:12])=[N:1]2

Participants

4

Reactant 2

HCID 5789982-Amino-6-fluorobenzylamineHCID 21875354Triethylorthoaceate

Product 1

HCID 178432155HCID 178432155, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2-amino-6-fluorobenzylamine (1.1 g, 7.86 mmol) and triethylorthoacetate (1.58 mL, 8.64 mmol) in ethanol (30 mL) was heated at 80° C. for 14 h. The reaction mixture was allowed to cool to room temperature and evaporated in vacuo. The yellow oil was triturated with diethyl ether to give the title compound as white solid (0.74 g, 57%). Mass spectrum (API+): Found 165 (MH+). C9H9N2F requires 164.

Workup

  1. customevaporated in vacuo
  2. customThe yellow oil was triturated with diethyl ether

Sources & evidence

ORD record
ord-883b5f5678a0494db9e22991200cba7a
Source dataset
uspto-grants-2007_07
Patent number
US07244726B2

Reaction notes

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