1,2-Dibromoethane → 5-(2-Bromoethoxy)-7-fluoro-2-methylquinoline

HRID 1295572Notes

Reaction equation

HRID 1295572 reaction equation
Br.[F:2][C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([CH3:13])=[N:10]2)=[C:5]([OH:14])[CH:4]=1.[Br:15][CH2:16][CH2:17]Br>>[Br:15][CH2:16][CH2:17][O:14][C:5]1[CH:4]=[C:3]([F:2])[CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][C:9]([CH3:13])=[N:10]2

Participants

3

Reactant 2

HCID 78391,2-DibromoethaneHCID 1355530137-Fluoro-5-hydroxy-2-methylquinoline hydrobromide

Product 1

HCID 179651425-(2-Bromoethoxy)-7-fluoro-2-methylquinolineYield 91%

Procedure

The title compound was prepared from 7-fluoro-5-hydroxy-2-methylquinoline hydrobromide and 1,2-dibromoethane using a similar procedure to Description 13, in 91% yield.

Sources & evidence

ORD record
ord-2115d1601e974fb7988fa00f282f70af
Source dataset
uspto-grants-2007_07
Patent number
US07244726B2

Reaction notes

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