HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl phosphite → Diethyl 3-Nitrobenzylphosphonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | Benzene, 1-(bromomethyl)-3-nitro- | HCID 77568 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Diethyl 3-Nitrobenzylphosphonate | HCID 13675396 | 68% |
Reaction Steps
A mixture of 3-nitrobenzyl bromide (17.3 g, 0.08 mol), triethyl phosphite (13.3 g, 0.08 mol) in toluene (200 mL) was stirred at reflux for 24 h. The reaction mixture was cooled and evaporated in vacuo. Chromatography of the residues on SiO2 eluting from 0–100% ethyl acetate in petroleum ether (60–80° C.) gave the title compound (14.8 g, 68%) as a yellow liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244726B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-0889e9f234de4bcb8da5c6f93585c8f8 |
| Source note | uspto-grants-2007_07 |