HuagongsheHuagongshe Chemistry Print Report · For research reference only
SB-649,915 → 6-{1-[2-(2-Methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-3,4-dihydro-2H-benzo[1,4]oxazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | SB-649,915 | HCID 10296414 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Product | 6-{1-[2-(2-Methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-3,4-dihydro-2H-benzo[1,4]oxazine | HCID 10309968 | 54.6% |
Reaction Steps
The title compound (0.228 g, 54%) was prepared by reduction of 6-{1-[2-(2-methylquinolin-5-yloxy)ethyl]piperidin-4-ylmethyl}-4H-benzo[1,4]oxazin-3-one (0.431 g, 1 mmol) with lithium aluminium hydride as described in Example 3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07244726B2 |
| Source dataset | uspto-grants-2007_07 |
| ORD ID | ord-3f890433af43453d8505eb44a7290eaf |
| Source note | uspto-grants-2007_07 |