4-Methanesulfonyl-6-(piperazin-1-ylmethyl)-3,4-dihydro-2H-benzo[1,4]oxazine → 4-Methanesulfonyl-6-{4-[2-(2-methylquinazolin-5-yloxy)ethyl]piperazin-1-ylmethyl}-3,4-dihydro-2H-benzo[1,4]oxazine

HRID 1295590Notes

Reaction equation

HRID 1295590 reaction equation
[CH3:1][S:2]([N:5]1[C:10]2[CH:11]=[C:12]([CH2:15][N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].CS(O[CH2:27][CH2:28][O:29][C:30]1[CH:39]=[CH:38][CH:37]=[C:36]2[C:31]=1[CH:32]=[N:33][C:34]([CH3:40])=[N:35]2)(=O)=O>>[CH3:1][S:2]([N:5]1[C:10]2[CH:11]=[C:12]([CH2:15][N:16]3[CH2:17][CH2:18][N:19]([CH2:27][CH2:28][O:29][C:30]4[CH:39]=[CH:38][CH:37]=[C:36]5[C:31]=4[CH:32]=[N:33][C:34]([CH3:40])=[N:35]5)[CH2:20][CH2:21]3)[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 112091394-Methanesulfonyl-6-(piperazin-1-ylmethyl)-3,4-dihydro-2H-benzo[1,4]oxazineHCID 179651395-(2-(Methanesulfonyloxy)ethoxy)-2-methylquinazoline

Product 1

HCID 101523024-Methanesulfonyl-6-{4-[2-(2-methylquinazolin-5-yloxy)ethyl]piperazin-1-ylmethyl}-3,4-dihydro-2H-benzo[1,4]oxazine

Procedure

The title compound was prepared from 4-methanesulfonyl-6-(piperazin-1-ylmethyl)-3,4-dihydro-2H-benzo[1,4]oxazine and 5-(2-(methanesulfonyloxy)ethoxy)-2-methylquinazoline following the method of Example 1.

Sources & evidence

ORD record
ord-b4e55a3be5ea459b80c99c2cd36ce961
Source dataset
uspto-grants-2007_07
Patent number
US07244726B2

Reaction notes

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