Ammonium formate → HCID 10194532, compound

Participants

Reaction Steps

6-{1-[2-(Methylquinolin-5-yloxy)ethyl]piperidin-4-ylidenemethyl}-1,3-dihydroindol-2-one (150 mg; 0.36 mmol) was dissolved in a mixture of methanol (20 ml) and tetrahydrofuran (20 ml). Ammonium formate (229 mg; 3.6 mmol) was added, followed by 10% palladium on carbon (150 mg), and the resulting mixture stirred vigorously at ambient temperature for 2 h. The reaction mixture was filtered through Kieselguhr and the filtrate evaporated to dryness under reduced pressure. Chromatography on SiO2, eluting with 10% aq. ammoniacal methanol in dichloromethane (5:95), gave the title compound (150 mg; 100%) as a white foam.

Provenance & Evidence