Water → 1-Fluoro-4-(2-methyl-propenyl)-2-trifluoromethyl-benzene

Participants

Reaction Steps

4.3 g (18.2 mmol) 1-(4-fluoro-3-trifluoromethyl-phenyl)-2-methyl-propan-1-ol and 1.0 g (5.3 mmol) p-toluenesulphonic acid monohydrate in 100 mL toluene are refluxed for 3 hours using the water separator. Then the reaction mixture is combined with water and made alkaline with 1 N sodium hydroxide solution. After separation of the organic phase this is washed with water, dried with sodium sulphate and evaporated down. The oil remaining is further reacted directly.

Provenance & Evidence